The choice of solvent used depends on the nature and physicochemical properties of the drug substance and the intended use of the formulation. To continue reading, click on the page buttons below…, Your email address will not be published. The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Analgesic oral suspension 5. The suspension includes high molecular weight polyethylene glycol as a suspending agent. Read Also: Excipients Used In the Formulation of Liquid Dosage Forms. D. Suspensions of precipitate forming solids • Resinous materials when mixed with water become precipitated • Thickening agent is used • Example: Compound bentonite tincture, Tolune tincture 14 15. The formation of foams during manufacturing processes or when reconstituting powder for suspension can be undesirable and disruptive. Most of the suspensions you encounter in everyday life consist of solid particles in liquids, but suspensions can also form from two liquids or even from a solid or liquid in a gas. All Rights Reserved . Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. Pharmaceutical Suspensions, F rom F ormulation Development to Manufacturing. K M.Pharm Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. In addition, disagreeable tastes can be masked by a suspension of the drug or a derivative of the drug, an example of the latter being the drug chloramphenicol palmitate. List of Pharmaceutical dosage forms Author: European Medicines Agency Last modified by: Angwin Jonathan Telling Them Apart . In a few instances, viscous nonaqueous solvents, such as propylene glycol and polyethylene glycols, are used as vehicles to impart stability to suspended drug particles. The internal phase consisting of insoluble solid particles having a specific range of size which is maintained uniformly through out the suspending vehicle with aid of single or combination of suspending agent. Pharmaceutical Suspensions, From Formulation Development to Manufacturing should serve as a good resource for pharmaceutical scientists, process scientists and chemical engineers involved in the areas of research and development of pharma-ceutical suspension dosage forms, and for … … 19-The lime slurry . A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. Colloids can be distinguished from solutions using the Tyndall effect.A beam of light passing through a true solution, such as air, is not visible. Pharmaceutical applications of colloids Definition Subject: Pharmacy , Science Topic: Article Interface and colloid science – Interface and colloid science is a branch of chemistry dealing with colloid s, heterogeneous systems consisting of a mechanical mixture of particles between 1 nm and 1000 nm dispersed in a continuous medium. Assistant Professor. Antibacterial oral suspension 3. If you continue browsing the site, you agree to the use of cookies on this website. The most commonly used vehicle for the formulation of pharmaceutical suspensions is purified water. Among these, the most commonly used ones are the anionic and non-ionic surfactants. Active substances are rarely administered alone. Basically, it is an oral suspension in liquid form. Sucrose has a preservative action at concentrations greater than or equal to 67% w/v. Now customize the name of a clipboard to store your clips. describe a xanthan gum and hydroxypropylmethylcellulose liquid excipient for suspending solid pharmaceutically active compounds. Examples of flocculating agents are: Substances commonly used buffering agents in pharmaceutical suspensions include salts of week acids such as carbonates, citrates, gluconates, phosphate, and tartrates. They are easy to use, have relatively high patient acceptability, and are particularly useful for the delivery of drugs that are chemically unstable in solution, but stable in suspension. For example, Triamcinolone Acetonide Injectable suspension and insulin zinc suspension are intended for intramuscular (or intra-articular) and subcutaneous administration respectively. Antifungal oral suspension Vignan Pharmacy College 7 SOME MARKETED SUSPENSIONSTYPES OF PHARMACEUTICAL SUSPENSIONS 8. Maintain/ optimize anti-microbial effectiveness. The medical syrup or pharmaceutical syrup is actually used as a vehicle for medicine. There are three basic types of suspension components: linkages, springs, and shock absorbers. Required fields are marked *. Cholera vaccine X-ray contrast agent are also formulated as suspension. The dissolution of a Clipping is a handy way to collect important slides you want to go back to later. Pharmaceutical Applications of suspensionsPharmaceutical Applications of suspensions Suspension can be formulated for parentral application in order to control rate of drug absorption, E.g. Pharmaceutical science is an umbrella that covers all sciences related to pharmaceuticals or pharmacotherapy. Settling or sedimentation is pro… Suspending agent excipients help active pharmaceutical ingredients stay suspended in the formulation and prevent caking at the bottom of the container. What are the different types of suspension systems? No. A pharmaceutical suspension is a coarse dispersion in which insoluble particles, generally greater than 1 µm in diameter, are dispersed in a liquid medium, usually aqueous. Your email address will not be published. Formulation of suspension The three steps that can be taken to ensure formulation of an elegant pharmaceutical suspension are: 1. Help improve bioavailability of active drugs. Pharmaceutical Suspensions, From Formulation Development to Manufacturing provides the reader with a broad overview of suspension drug product technology. S.Deepak Examples of suspension aerosol products include antibiotics, steroids, and antiasthmatic drugs (Kulkarni and Shaw, 2016). These very small amounts of powder mean that it is not possible to manufacture tablets containing only this drug. Buffers are mixture of a weak acid or base and one of its salts which when dissolved in a solvent will resist any change in pH when an acid or base is added. The large surface area of dispersed drug ensures a high availability for dissolution and hence absorption. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15 μg to 200 μg. Depending on their intended route . Suspensions of insoluble drugs may also be used externally, often as protective agents. Wetting agents/ surfactants. It is usually used as a flavored vehicle for drugs. Table 8.1: Some examples of taste masked suspensions 8.2 Nano-Suspension Nano-suspension of potent insoluble active pharmaceutical ingredient will become improved drug delivery formulations when delivered to at sizes less than 50 nm. Examples of pharmaceutical suspensions Composition of a pharmaceutical suspension 34. Enter your email address to subscribe to this blog and receive notifications of new posts by email. Anthelmentic oral suspension 6. should serve as a good resource for pharmaceutical scientists, ... For example, if a water-soluble dye is added . You can tell suspensions from colloids and solutions because the components of suspensions will eventually separate. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. You can tell suspensions from colloids and solutions because the components of suspensions will eventually separate. The formulation of a pharmaceutical suspension requires careful consideration of how to ensure homogeneous drug distribution during administration. Sweeteners can be added in small quantities (e.g. Pack-sizes of … VIGNAN PHARMACY COLLEGE. Muhammad Adeel Pharm-D G.C University Faisalabad 3. Since many of the surfactants in this group are esters, they are usually susceptible to hydrolysis under conditions of high or very low pH. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. are often added as solubilizers, as well as base sweeteners. Solvents, such as alcohol, glycerin, and propylene glycol, may also have some preservative effect depending on their concentration. Some ionic preservatives such as sodium benzoate may interact or form complexes with other suspending ingredients thus reducing their preservative efficacy. Approved by PCI,AICTE, New Delhi. A detailed description about Pharmaceutical Suspensions and Emulsions or Disperse systems was given in this ppt. aspartame) or larger amounts when also used as bulking agent (e.g. Dry powders for oral suspension (antibiotic) 4. An aqueous suspension is a useful formulation system for administering an insoluble or poorly soluble drug. For this reason, effective aqueous concentration of the preservative must be monitored and controlled. Pharmaceutical excipients by definition are substances other than the prodrug or active pharmaceutical ingredient which are added in the manufacturing process or are contained in a finished dosage form. Generally, the pH of pharmaceutical suspension should be kept between 7.0 – 9.5 preferably between 7.4 – 8.4. Partitioning into micelles (from surfactants), Adsorption onto surfaces (container, thickening agent and suspended particles). Published by Pharmaceutical Press 1 Lambeth High Street, London SE1 7JN, UK 1559 St. Paul Avenue, Gurnee, IL 60031, USA The NHS Pharmaceutical Quality Assurance Committee 2010 is a trade mark of Pharmaceutical Press Pharmaceutical Press is the publishing division of the Royal Pharmaceutical Society of Great Britain First published 2010 Suspending agent excipients help active pharmaceutical ingredients stay suspended in the formulation and prevent caking at the bottom of the container. Examples of these include: ... formulated as an alternative-dosage form, e.g. UNDER THE ESTEEMED GUIDANCE OF Composition of a pharmaceutical suspension Types of preservatives that might be used in suspensions - Alcohol 5-10% - Benzoates 0.1-0.3% - Parabens 0.02-0.2% - Phenols 0.2-0.5% - Quats 1:10,000- 1:50,000 - … Below, we review five examples of formulations and how best you should approach each problem. Surfactant or surface-active agent is a general name for materials that possess surface activity; in solution, they tend to orient at the surface of the liquid. Affiliated to JNTU,Kakinada. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients sus- pended in a suitable vehicle. Other examples of common suspensions . 16-Amoxicillin (antibiotic) 17-Powder Makeup . Depending on the nature of the polar area, surfactants can be anionic (e.g., Sodium lauryl sulfate, docusate sodium), cationic (e.g., benzalkonium chloride, phosphatidylcholine), amphoteric (e.g., betaines or sulfobetaine and natural substances such as amino acids and phospholipids) and nonionic (e.g., polyoxyethylene sorbitan fatty acid esters). Telling Them Apart . A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. Buffering agents/ pH modifiers are added to suspensions to. Preservatives are agents that protect pharmaceutical formulations against microbial spoilage and prevent increased risk of contamination by opportunistic microbial pathogens from excipients or introduced externally, resulting in potential health consequences. Suspension should be redispersible on shaking A relatively narrow particle size distribution forms If the particle size distribution is wide then Ostwald ripening may be seen when temperature changes. 4) Suspension can have depot therapy: small volume drugs can be incorporated. 13-Moisturizing creams or face creams . 11AB1R0050 Finally, drugs in suspension are chemically more stable than in solution. It is unlikely to be used in commercial products due to its cariogenic potential but may be encountered in extemporaneous products, albeit more likely in solution formulations. 1. These agents aid wetting and dispersion of hydrophobic active pharmaceutical ingredients and they usually act by reducing interfacial tension between solids and liquids in suspensions. Other examples of solvents used in suspension formulation include alcohol, acetic acid, acetone, ethyl acetates, etc. Notify me of follow-up comments by email. You can change your ad preferences anytime. Emulsion ppt prepared by yasir yaqoob !!! 18-Ash in a volcanic eruption . This website uses cookies. Pharmaceutical solutions may contain a range of excipients, each with a defined pharmaceutical purpose. pharmaceutical suspensions, this state is physically unstable. PARENTERAL SUSPENSION: AN OVERVIEW RAJESH M. PATEL *Department of Pharmaceutics and Pharmaceutical Biotechnology, S.K.Patel College of Pharmaceutical Education & Research, Ganpat University, Kherva­382711. 20-Milk powder . 6. One of the properties of a well-formulated suspension is that it can be easily re-suspended by the use of moderate agitation or shaking. Pharmaceutical solutions may be generally defined as liquid preparations in which the therapeutic agent and the various excipients are dissolved in the chosen solvent system. Or pharmaceutical syrup is actually used as a immunizing agent are often formulated as suspension.E.g we review examples! 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